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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMG6
All Species:
15.76
Human Site:
S321
Identified Species:
38.52
UniProt:
Q86US8
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q86US8
NP_060045.4
1419
160462
S321
G
L
G
P
R
R
S
S
E
R
K
R
H
L
E
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_548319
1527
171816
S430
P
D
E
P
R
R
S
S
E
R
K
K
H
L
E
Cat
Felis silvestris
Mouse
Mus musculus
P61406
1418
160477
S320
V
L
G
S
R
R
S
S
E
R
K
K
H
L
E
Rat
Rattus norvegicus
NP_001099278
1472
165733
S374
G
L
G
S
R
R
S
S
E
R
K
K
H
L
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509588
959
106964
Chicken
Gallus gallus
XP_001234885
1419
159567
S360
A
Y
A
S
N
R
V
S
D
R
K
K
R
S
E
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_696418
1546
172554
T421
G
Q
Q
F
S
A
R
T
L
E
R
A
T
G
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651321
948
108473
Honey Bee
Apis mellifera
XP_393289
1688
192186
S532
N
E
I
V
N
I
T
S
N
I
S
A
E
H
P
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_794411
1745
199805
R453
A
V
E
I
Q
K
L
R
A
K
K
E
K
M
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
85.5
N.A.
90.8
88
N.A.
40.7
69.6
N.A.
49.3
N.A.
21.7
29.7
N.A.
24.4
Protein Similarity:
100
N.A.
N.A.
88.7
N.A.
95.1
91.9
N.A.
49.8
80.3
N.A.
64.4
N.A.
36.2
45.5
N.A.
41.7
P-Site Identity:
100
N.A.
N.A.
73.3
N.A.
80
80
N.A.
0
33.3
N.A.
6.6
N.A.
0
6.6
N.A.
13.3
P-Site Similarity:
100
N.A.
N.A.
80
N.A.
86.6
93.3
N.A.
0
46.6
N.A.
26.6
N.A.
0
13.3
N.A.
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
20
0
10
0
0
10
0
0
10
0
0
20
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
10
0
0
0
0
0
0
10
0
0
0
0
0
10
% D
% Glu:
0
10
20
0
0
0
0
0
40
10
0
10
10
0
50
% E
% Phe:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
30
0
30
0
0
0
0
0
0
0
0
0
0
10
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
40
10
0
% H
% Ile:
0
0
10
10
0
10
0
0
0
10
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
10
0
0
0
10
60
40
10
0
0
% K
% Leu:
0
30
0
0
0
0
10
0
10
0
0
0
0
40
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% M
% Asn:
10
0
0
0
20
0
0
0
10
0
0
0
0
0
0
% N
% Pro:
10
0
0
20
0
0
0
0
0
0
0
0
0
0
10
% P
% Gln:
0
10
10
0
10
0
0
0
0
0
0
0
0
0
10
% Q
% Arg:
0
0
0
0
40
50
10
10
0
50
10
10
10
0
0
% R
% Ser:
0
0
0
30
10
0
40
60
0
0
10
0
0
10
0
% S
% Thr:
0
0
0
0
0
0
10
10
0
0
0
0
10
0
0
% T
% Val:
10
10
0
10
0
0
10
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _